On the dairy, long calving intervals lead to lower lifetime milk production and lower profitability. Primary causes of long calving intervals are poor heat detection, waiting too long after calving to begin breeding and low conception rates.1

A cow must be pregnant by 85 days postpartum in order to achieve optimum milk production and calve every 12-1/2 months.1 Prostaglandins are helpful in bringing groups of animals into heat. Prostaglandins are naturally produced by the uterus and are responsible for the regression of the corpus luteum (CL).

Because prostaglandins act on the corpus luteum, they can only be effective in cycling cattle. They should not be used prior to approximately 30 days in milk (DIM), because few cows will have a CL that is able to respond. Use in cycling cows, however, usually results in estrus 2 to 5 days after treatment.

Benefits of prostaglandins include:2

  • Shortened time to first service
  • Increased estrus detection efficiency
  • Improved uterine health and first-service conception rate

Prostaglandins can also be used to treat endometritis and induce abortion.

There are two major types of prostaglandins:

  • A uterine-derived form (dinoprost tromethamine)
  • A synthetic form that mimics natural PGF2α (cloprostenol sodium)

In a study, cloprostenol and dinoprost both performed well with cloprostenol increasing estrus detection rates in first parity cows by 42 percent and dinoprost increasing detection by 34 percent (P<0.01).3

SYNCHSURE™ (cloprostenol sodium) is a choice in cloprostenol prostaglandins to help take the guesswork out of breeding. SYNCHSURE is flexible to fit into an operation’s one- or two-dose protocol. When using a single injection, managers can expect standing heat to occur within 2 to 5 days. When using the dual injection method, the second injection is administered 11 days after the first, with standing heat expected 2 to 5 days following the second injection.

Plus, SYNCHSURE fits easily into the dairy environment with a 6-month shelf life after opening and no refrigeration required. In addition, it does not have a meat or milk withdrawal time, making it an excellent choice for reproductive management.

When it comes to herd reproduction, missing even one heat can be detrimental to overall efficiency and profitability. So be sure – SYNCHSURE.

SYNCHSURE is available by prescription only. Talk to your veterinarian, call 1-888-MERIAL-1, or visit SYNCHSURE.com for prescribing information and to learn more.

IMPORTANT SAFETY INFORMATION: FOR ANIMAL USE ONLY, NOT FOR HUMAN USE. KEEP OUT OF REACH OF CHILDREN. Women of child-bearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. In the early stages women may be unaware of their pregnancies. SYNCHSURE is readily absorbed through the skin and may cause abortion and/or bronchospasms: direct contact with the skin should therefore be avoided. Accidental spillage on the skin should be washed off immediately with soap and water.

™SYNCHSURE is a trademark of Merial.

©2016 Merial, Inc., Duluth, GA. RUMIOTD1632 (12/16)


1Graves W. Dairy herd synchronization programs. University of Georgia Extension Publication. B1227.

2O’Connor M. Estrous synchronization programs for the dairy herd. Penn State University Extension Publication DAS 97-8.

3Pursley JR, et al. Compared to dinoprost tromethamine, cloprostenol sodium increased rates of estrus detection, conception and pregnancy in lactating dairy cows on a large commercial dairy. Theriogenology. 2012;78(4):823-9.