Antiviral treatment of PI calves

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Dr. Benjamin Newcomer, Auburn University, looked at the use of a novel antiviral compound (DB772) in the treatment of calves persistently infected (PI) with bovine viral diarrhea virus. “It seems from our research that the compound does affect the viral load in PI calves,” Newcomer says. “However, given the high mutation rate of BVDV, what we saw was a selection for a mutant strain of BVDV that was resistant to the antiviral effects of DB772.” Therefore, he adds, DB772 is not effective at treating PI animals and there is still currently no cure or treatment for such animals.

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