Immunocompetence of FMD-infected cattle

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Geni Wren BioMed Central has available a new paper on the immunocompetence of cattle infected with foot and mouth disease virus (FMDV).

Research by Windsor, et al, showed that infection of cattle with foot-and-mouth disease virus results in the development of long-term protective antibody responses. In contrast, inactivated antigen vaccines fail to induce long-term protective immunity.

The abstract says differences between susceptible species have also been observed during infection with FMDV, with cattle often developing persistent infections whilst pigs develop more severe symptoms and excrete higher levels of virus. Cattle exposed to FMDV were found to be viraemic and produced neutralising antibody, consistent with previous reports. In contrast to previous studies in pigs these cattle did not develop leucopenia, and the proliferative responses of peripheral blood mononuclear cells to either mitogen or third party antigen were not suppressed.

The results suggest that there was no generalized immunosuppression during the acute phase of FMDV infection in cattle.

Cattle remain immunocompetent during the acute phase of foot-and-mouth disease virus infection
Miriam A Windsor, B VERONICA Carr, Bartomiej Bankowski, Debi Gibson, Elizabeth Reid, Pip Hamblin, Simon Gubbins, Nicholas Juleff and Bryan Charleston

Veterinary Research 2011, 42:108 doi:10.1186/1297-9716-42-108. Published: 20 October 2011



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