While performing a topical spray trial, researchers scored the rear feet of all cows for severity of pain, lesion size and color. They found that lesion scores were more prevalent in the larger breeds, as indicated in the table below:
| Breed | Number of cows in the trial | Number of cows with lesion scores | Percent |
| Holstein | 132 | 120 | 90 |
| Brown Swiss | 10 | 9 | 90 |
| Jersey | 26 | 5 | 19 |
| Ayrshire | 11 | 6 | 45 |
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