Even though the liberal groups have little to no influence with conservatives, they plan to bombard members with petitions, visits, rallies and calls.
"It doesn't matter where they turn, but there will be someone telling them they have to pass immigration reform," said Kica Matos, spokeswoman for a coalition of immigrant rights groups in 30 states.
The coalition, which includes the Service Employees International Union, said it would spend upwards of $1 million to mobilize people, advertise on the radio and hold town halls.
But it will be a tough slog. Boehner has said he will not allow the House to vote on a bill that does not have the support of the majority of House Republicans.
Mark Krikorian, executive director of the Center for Immigration Studies, a think tank that favors lower levels of immigration, said the lobbying was unlikely to change opinions in the House.
"They can have all the panel discussions and the press conferences they want," he said. "I don't think those kinds of efforts are really going to move a lot of votes in the House - or move any votes in the House, actually."