ZuprevoTM (tildipirosin) is a novel, new macrolide antibiotic for the management of bovine respiratory disease (BRD) that offers excellent combination of effectiveness and convenience.
ZUPREVO is indicated for the treatment of BRD associated with Mannheimia haemolytica, Pasteurella multocida and Histophilus somni in beef and non-lactating dairy cattle, and for the control of respiratory disease in beef and non-lactating dairy cattle at high risk of developing BRD associated with Mannheimia haemolytica, Pasteurella multocida and Histophilus somni. These bacterial pathogens are commonly associated with respiratory disease in cattle.
ZUPREVO gets its combination of effectiveness, bacteriostatic and bactericidal activity from its unique 16-member, tribasic molecular structure. The macrolides inhibit protein synthesis at the ribosomal level. Because of its structure, ZUPREVO offers a distinctive combination of performance properties; prolonged concentration in lung tissue (site of action) and bronchial fluids, and rapid absorption in the system*.
*Studies show that tildipirosin is rapidly absorbed from the site of injection, reaching peak plasma concentrations in just 45 minutes. Tildipirosin also yields higher and more persistent plasma concentrations. In trials, lung concentrations of tildipirosin in cattle treated with ZUPREVO were found to be above 1 µg/g after 28 days.
Tildipirosin also has the lowest single dose volume of any BRD treatment available – 1 mL per 100 lbs. of bodyweight, subcutaneously, with a maximum injection volume of 10 mL per injection site – which means fewer injections in large animals. It’s highly soluble and the formulation is easy to inject, even in cold temperatures.
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